Leptospirosis is a cause of reproductive loss in breeding herds and has been reported in swine from all parts of the world. When it is first introduced into a susceptible breeding herd, or during periods of waning herd immunity, it can cause very appreciable losses through abortion, or the full-term birth of dead pigs, or weak pigs of reduced viability or infertility. ERYSENG® PARVO/LEPTO is a new octavalent combined parvovirus, erysipelas and leptospira vaccine adjuvanted with HIPRAMUNE® G^d. The objective of this study was to assess the efficacy of the ERYSENG® PARVO/LEPTO vaccine on swine farms with reproductive problems due to leptospirosis.