Clostridioides difficile is a gram-positive, strict anaerobic rod, spore forming bacterium known to infect and cause clinical disease in several different species including humans and swine. The association between C. difficile and enteric disease became clear after the introduction and widespread use of antibiotics.

C. difficile is one of the most common causes of enteric disease in neonates’ piglets. Despite the importance of C. difficile associated disease (CDAD) in swine medicine the risk factors have not been extensively investigated. The objective of this article is to discuss some of the known risk factors associate with CDAD.