RHINISENG® is a new vaccine against progressive (PAR) and non-progressive atrophic rhinitis (NPAR) indicated for pregnant sows and gilts to passively protect their offspring. The RHINISENG® recommended vaccination scheme includes a basic vaccination scheme (vaccination 8-6 weeks before farrowing and revaccination 4-3 weeks before farrowing) and a booster dose (4-3 weeks before the subsequent farrowing). This study evaluated the vaccine pre-clinical safety under experimental conditions.
RHINISENG®: Safety of the basic vaccination scheme vaccination and revaccination and the booster vaccination
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Swine
The mean body temperature did not exceed 38.7ºC in
vaccinated sows (38.66 ± 0.38ºC after revaccination),
always reaching the maximum value 6 hours after vaccine
administration (Figure 1). The normal temperature for
sows in gestation is 38.7 ± 0.3 ºC (Straw et al., 1999). No
abnormal local or systemic reactions were observed.
Both, the basic vaccination scheme and the booster scheme
had no effects on the reproductive performance of sows. No
abortions were observed over the study period or teratogenic
...
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