Role of Bordetella bronchiseptica in the atrophic rhinitis challenge model used for Rhiniseng® pre-clinical efficacy testing

Publications

Swine

Authors

Montané, J.; Monells, M.; Torrents, D.; March, R.; Sitjà, M.; Camprodon, A.

The toxigenic Bb strain used in the challenge model for

RHINISENG® pre-clinical efficacy testing demonstrated

its ability to cause atrophic rhinitis lesions by its own,

even more than the toxigenic Pm strain used in this

study (Figure 1). It has been described that expression

of the dermonecrotic toxin by Bb is not necessary for

predisposing to infection with toxigenic Pm, therefore the Bb strain selected for vaccine

efficacy testing was more pathogenic than required.

Moreover, the infection dose of Bb used in...

In this work, the B. bronchiseptica strain to be used for RHINISENG® pre-clinical efficacy testing was characterized in an in vivo model to evaluate its ability to cause atrophic rhinitis lesions by its own.