We present here three studies focused on demonstrating the safety of the new vaccine HIPRABOVIS® IBR Marker Live due to the intrinsic characteristics of the double deleted strain (strain CEDDEL) that contains 3 trials. Trial 1: dissemination, shedding and latency; Trial 2: latency, reactivation and re-excretion; Trial 3: abortigenicity and passage through the placenta.
Safety of a new attenuated IBR live vaccine with double genetic deletion gE-tk- dissemination, latency/re-excretion and abortigenicity: 3 trials assaying very high doses
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Cattle
The safety of a new double deleted (gE-tk-) attenuated live IBR vaccine (Hiprabovis®IBR Marker Live, HIPRA) was demonstrated in relation to the intrinsic characteristics of the double deleted strain CEDDEL: There was no dissemination or shedding of the virus after vaccination with a very high overdose. No latency (trigeminal ganglia) was detected in any trial. After dexamethasone treatment there were no evidences of reactivation or viral re-excretion. The vaccine virus is not abortigenic: it did not cross the placenta”.
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