Necrotic enteritis (NE) is an enteric poultry disease, caused by Clostridium perfringens. Several are the predisposing factors to the disease, including diet and Eimeria spp.

Coccidiosis vaccines are indicated to decrease the intestinal lesions caused by Eimeria species which are a known predisposing factor to NE. Feed additives can be an alternative solution to antimicrobials. The combination of vaccination against coccidiosis and the supplementation of the diet with feed additives could be a composite approach to the control of NE triggered by Eimeria spp. infestation in broilers.

Therefore, the objective of these two studies was to test the efficacy of an attenuated coccidiosis vaccine in combination with different feed additives in preventing a loss of production performance and intestinal lesions in broilers challenged with necrotic enteritis.