This work shows the results of one study where the safety and the efficacy of SUISENG® (a vaccine against the Neonatal Piglet Colibacillosis, C. perfringens and C. novyi enterotoxicosis) were assessed. Applying the basic vaccination and the Revaccination to pregnant sows, the efficacy was evaluated by means the serological response, the transfer of maternal immunity and the clinical signs in challenged piglets with two pathogenic strains of E. coli.