Sudden death of sows has become one of the vulnerable problems in swine production, and the confirmation rate of Clostridium novyi has increased in diagnostic centers. Substantial economic losses have been brought about not only by sow mortality, but also by neonatal diarrhea after the total ban of antibiotics in pre-mix feed additives. To improve this situation, SUISENG® (Hipra) containing fimbriae of E.coli and toxoids C/ostridium perfringens type C and C/ostridium novyi, has been applied in four farms since September 2016.