Neonatal diarrhoea is an important and devastating disease to swine producers, responsible of a big economic impact in farms worldwide. In general, most of the neonatal infections can be prevented by passive calostral and lactogenic immunity obtained by vaccination of the sow. Neonatal diarrhoeas induced by E.coli are commonly prevented through sow vaccination that are booster vaccinated 2-3 weeks before farrowing.