Reliable data on the worldwide presence of verotoxigenic strains of Escherichia coli (VTEC) producing verotoxin-2e (Vt2e) could explain the overall prevalence of swine edema causing a deleterious economic impact in the swine industry. Therefore, a systematic literature review on the prevalence of Vt2e was performed to evaluate the information about the presence of swine edema disease in swine farms.