Since 2011, an action plan on the rational usage of antimicrobials has been implemented by the EU Commission (Cars 2014). Antibiotics are the main measure used for the control of respiratory problems in cattle, while vaccination could be an alternative. The aim of this study was to demonstrate the efficacy under field conditions of a commercial vaccine containing Histophilus somni and Mannheimia haemolytica leukotoxoid (HIPRABOVIS® SOMNI/Lkt) in reducing respiratory problems caused by these bacteria in cattle and in reducing the number of drug treatments.