Current knowledge on PRRS virus immunology is still limited but it seems clear that modified live vaccines (MLV) are a reasonable choice for the immunisation of pigs (1). Cell-mediated responses after MLV vaccination could be responsible for limiting the duration of viraemia, and consequently the spread of the virus (2). Recently, interest in intradermal vaccination has increased due to research on the skin and subcutaneous tissues immunology. Although the intradermal PRRSV vaccination has been investigated (3), the high variability between different virus isolates makes it advisable to assess the intradermal response for each vaccine strain. The aim of this study was to compare the cell-mediated immune response developed in gilts vaccinated intramuscularly and intradermally with UNISTRAIN® PRRS.
Heterologous cell-mediated immune responses against PRRS virus in gilts vaccinated intramuscularly and intradermally with UNISTRAIN® PRRS
ISERPD Congress, 2015
As expected, the variability of IFN-γ-SC responses observed among different strains was not related to the percentage of ORF5 similarity with the vaccine strain. Results demonstrated that the ID administration of UNISTRAIN® PRRS confers higher levels of cell-mediated immune response than using the IM route. This phenomenon suggests that ID route could be considered a candidate to develop future PRRS vaccines.
Related products
The first intradermal needle-free vaccine against Mycoplasma hyopneumoniae and PCV2, all in one, in suspension for injection
Live vaccine against porcine reproductive and respiratory syndrome (PRRS), in injectable freeze-dried tablet
Purified recombinant verotoxin 2e against edema disease, in suspension for injection
Inactivated vaccine, against progressive and non progressive swine atrophic rhinitis, in injectable suspension.
Inactivated vaccine against neonatal colibacillosis and Clostridium infections in swine, in injectable suspension
Inactivated vaccine against Clostridioides difficile and Clostridium perfringens type A infections in swine, in injectable suspension.
Inactivated vaccine against porcine parvovirus and swine erysipelas, in injectable suspension
Inactivated vaccine against swine erysipelas, parvovirosis and leptospirosis, in injectable suspension
Live vaccine against Aujeszky’s disease gE negative strain, in injectable freeze-dried tablet
Inactivated vaccine against swine erysipelas, in injectable suspension
Inactivated porcine against porcine parvovirus, in injectable suspension
Inactivated vaccine against enzootic pneumonia, in injectable suspension
Related services
Smart Vaccination by HIPRA is a revolutionary concept that combines: A smart vaccine including RFID technology in its label, a vaccination device which ensures precision and efficiency, and a new world of digital solutions in HIPRAlink Vaccination. All these elements are developed internally by HIPRA.
In Swine, the HIPRA SMART VACCINATION is spearheaded by our innovative MHYOSPHERE® PCV ID and UNISTRAIN® PRRS vaccines, the needle-free intradermal device Hipradermic® and the professional veterinary app HIPRAlink® Vaccination.
An innovative service based on data analysis that facilitates decision-making in swine
HIPRA Stats is a data analysis service for animal production companies.
Hipradermic® is an advanced needle-free injection device with wireless connectivity for the intradermal vaccination of pigs.
HIPRA University offers high quality training programmes in strategic areas of interest for professionals
Access an advanced diagnostic service with maximum comfort and reliability
