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Heterologous cell-mediated immune responses against PRRS virus in gilts vaccinated with UNISTRAIN® PRRS

Publications
Swine
Authors

Miranda,J.; Rodriguez-Ballarà, I.; Fenech, M.; Perozo, E.; Llopart, D.; Torrents, D.; Mateu, E.; Díaz, I.

Appeared in

International PRRS Congress, 2015

Genetic/antigenic diversity and variability in the immunobiological properties of the PRRSV (3,4) may compromise the heterologous protection generated by vaccination in PRRS control strategies. Although PRRS immunity is not yet fully understood, the significance not only of the NA but the cell-mediated immunity is important for a better understanding of vaccine performance (3). The present study showed that primo-immunization of naïve gilts with UNISTRAIN® PRRS induced a significant specific cell-mediated immunity against 5 heterologous PRRSV strains. The mean IFN-γ-SC response was...

Vaccination is one of the main tools to minimize porcine reproductive and respiratory syndrome (PRRS) impact in endemic areas. Current knowledge of PRRS virus (PRRSV) immunology is still limited but it seems clear that modified live vaccines (MLV) are a reasonable choice for the immunization of pigs.

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